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Lopixibat chloride

CAS No. 228113-66-4

Lopixibat chloride( LUM-001 | HP-625 )

Catalog No. M13626 CAS No. 228113-66-4

Lopixibat chloride (LUM-001, HP-625) is a potent, selectiove, oral inhibitor of sodium bile acid cotransporter and Ileal bile acid transporter (IBAT).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Lopixibat chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Lopixibat chloride (LUM-001, HP-625) is a potent, selectiove, oral inhibitor of sodium bile acid cotransporter and Ileal bile acid transporter (IBAT).
  • Description
    Lopixibat chloride (LUM-001, HP-625) is a potent, selectiove, oral inhibitor of sodium bile acid cotransporter and Ileal bile acid transporter (IBAT).Hypercholesterolemia Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    Maralixibat chloride reduces elevations in sBA levels, improves liver function, and reduces liver tissue damage, in a rat partial bile duct ligation model of cholestasis.
  • Synonyms
    LUM-001 | HP-625
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    ASBT Transporter
  • Recptor
    ASBT Transporter
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypercholesterolemia

Chemical Information

  • CAS Number
    228113-66-4
  • Formula Weight
    710.415
  • Molecular Formula
    C40H56ClN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (70.38 mM)
  • SMILES
    ——
  • Chemical Name
    1-(4-((4-((4R,5R)-3,3-dibutyl-7-(dimethylamino)-4-hydroxy-1,1-dioxido-2,3,4,5-tetrahydrobenzo[b]thiepin-5-yl)phenoxy)methyl)benzyl)-1,4-diazabicyclo[2.2.2]octan-1-ium chloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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